(Please Point to Flags to See the Structures)

NEWS:

August 5, 2014
Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment in the journal Structure MORE >>

July 10, 2014
Publication of Structural Basis for Smoothened Receptor Modulation and Chemoresistance to Anticancer Drugs in the journal Nature Communications MORE >>

May 1, 2014
Two publications of the human P2Y12 receptors in the journal Nature:
Agonist-bound P2Y12 MORE >>
Antagonist -bound P2Y12 MORE >>

April 21, 2014
Review on allosteric role of sodium in class A GPCR signaling in TiBS on-line MORE >>

March 23, 2014
Publication of Structure of the human P2Y12 receptor in the journal Nature: MORE >>

March 6, 2014
Publication of Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 in the journal Science: MORE >>

19 July – 23 July 2014
James Black Conference: Adrenoceptors and GPCRs - Where is Structure Leading? For MORE Information please GO TO >>

January 12, 2014
Publication of Molecular Control of δ-Opioid Receptor Signalling in the journal Nature: MORE >>

December 20, 2013
Publication of Serial Femtosecond Crystallography of G-Protein-Coupled Receptors in the journal Science: MORE >>

September 12, 2013
Publication of structure of the Human CCR5 Chemokine G-protein-coupled Receptor in the journal Science: MORE >>

July 17, 2013
Publication of Structure of the Human Glucagon Class B G-protein-coupled Receptor in the journal Nature: MORE >>

May 1, 2013
Publication of the human Smoothened Receptor structure - in the journal Nature: MORE >>

March 21, 2013
Publication of two Serotonin receptors structures 5-HT1B and 5-HT2B - in the journal Science: Serotonin 5-HT1B >> Serotonin 5-HT2B >>

March 19, 2013
GPCR Dock 2013 closed 3/2/2013. Results forthcoming this Summer, 2013

January 24, 2013
GPCR Dock 2013 starts Feb 1st. Spread the word and Register NOW at>>

November 26, 2012
SAB meetings for JCIMPT and GPCR Network to plan for the future.

August 24, 2012
Due to repeated requests for figures and artwork, popular items are being made available to the community for use.
You can download them HERE>>

August 1, 2012
Congratulations TSRI graduate student Eugene Chun on receiving the 2012 Margaret C. Etter student award from the BioMacromolecular Special Interest Group at ACA for his work on the membrane protein (GPCR) fusion toolchest

July 13, 2012
GPCRs as allosteric machines controlled by sodium, cholesterol, lipids, water in Science READ MORE >>

June 25, 2012
GPCR Network announces their Center and Scientific Advisory Board meeting to be held Monday, November 26, 2012 at TSRI.

May 17, 2012
Special issue of Nature highlighting all four opioid receptor crystal structures
kappa_opioid >> mu_opioid >> nociceptin >> delta_opioid >>

March 21, 2012
Publication of kappa-opioid receptor structure - in the journal Nature READ MORE >>

February 19, 2012
Publication of S1P1 receptor structure - in the journal Science READ MORE >>

January 19, 2012
Biased Signaling Pathways in β2-Adrenergic Receptor Characterized by 19F-NMR - in Science Express READ MORE >>

January 12, 2012
TiPS review on GPCR structural diversity and modularity, MORE Info>>

September 23, 2011
GPCR Network announces their Center and Scientific Advisory Board meeting to be held Monday, November 28, 2011 at TSRI.

Wednesday, August 3, 2011 - PSI:Biology GPCR Network structure researchers hold first annual GPCR Network meeting.

June 22, 2011 In an international collaboration with the Iwata laboratory, the human Histamine H1 receptor structure solved with 1st generation antihistamine. For MORE details please see >>

May 12, 2011 New GPCR Network Assessment Opens - ligand selection for opioid receptors, MORE Info>>

  • March 10, 2011
    Agonist bound structure of the A2A adenosine receptor highlights “conformationally selective agonist” published in Science Express. more>>

    MOVIE>> Conformational morphing trajectory between inactive, antagonist bound (yellow) and active, agonist bound (orange) forms of A2A adenosine receptor. Re: Xu, F., Wu, H., Katritch, V., Han, G.W., Jacobson, K.A., Gao, Z.G., Cherezov, V. and R,C. Stevens.(2011) Structure of an agonist-bound human A2A adenosine receptor. Science Express, March 10, 2011. Movie prepared with ICM-Pro (Molsoft LLC).